RNA modifications provided a new layer of post-transcriptional gene regulation.
Increasing evidences have demonstrated that the function of RNA modifications is
determined by RNA-modifying proteins that contains three classes of proteins:
writers, readers and erasers. Writers are proteins that place specific modifications
on RNA. Readers are proteins that bind selectively to modified forms of RNA.
Erasers are proteins that remove the specific modifications on RNA. The current
version of RNAWRE collected more than 2045 manually curated writers, readers and
erasers for the 6 major kinds of RNA modifications, namely Cap, m1A, m6A, m5C,
ψ and Poly A. These proteins are from animals.
RNAWRE will be helpful in revealing the mechanisms of RNA modifications.
